Lipogems: Pubblicazioni Scientifiche ~ IMAGE Medical Spa

Refractory Complex Crohn’s Perianal Fistulas: A Role for Autologous Microfragmented Adipose Tissue Injection

Silvio Laureti, MD, PhD,* Paolo Gionchetti, MD,† Alberta Cappelli, MD,‡ Laura Vittori, MD,* Federico Contedini, MD,§ Fernando Rizzello, MD, PhD,† Rita Golfieri, MD,‡ Massimo Campieri, MD,† and Gilberto Poggioli, MD*

Leggi articolo

Immunophenotyping of a Stromal Vascular Fraction from Microfragmented Lipoaspirate Used in Osteoarthritis Cartilage Treatment and Its Lipoaspirate Counterpart

Denis Polancec ^1,*, Lucija Zenic ¹, Damir Hudetz ^2,3,4, Igor Boric ^2,5,6, Zeljko Jelec ^2,4, Eduard RDenis Polancec ^1,*, Lucija Zenic ¹, Damir Hudetz ^2,3,4, Igor Boric ^2,5,6, Zeljko Jelec ^2,4, Eduard Rod ^2,4, Trpimir Vrdoljak ^2,3,4, Andrea Skelin ^2,7, Mihovil Plecko ² , Mirjana Turkalj ^1,4,8, Boro Nogalo ^1,4and Dragan Primorac ^{1,2,4,6,9,10,11,*od 2,4}, Trpimir Vrdoljak ^2,3,4, Andrea Skelin ^2,7, Mihovil Plecko ² , Mirjana Turkalj ^1,4,8, Boro Nogalo ^1,4and Dragan Primorac ^{1,2,4,6,9,10,11,*}

Leggi articolo

1 Srebrnjak Children’s Hospital, HR-10000 Zagreb, Croatia; lzenic@bolnica-srebrnjak.hr (L.Z.); turkalj@bolnica-srebrnjak.hr (M.T.); nogalo@bolnica-srebrnjak.hr (B.N.)

2 Specialty Hospital St. Catherine, HR-49120 Zabok, Croatia; damir.hudetz@svkatarina.hr (D.H.); igor.boric@svkatarina.hr (I.B.); zeljko.jelec@svkatarina.hr (Z.J.); Eduard.rod@svkatarina.hr (E.R.); trpimir.vrdoljak@svkatarina.hr (T.V.); andrea.skelin@svkatarina.hr (A.S.); mihovil.plecko@gmail.com (M.P.)

3 Clinical Hospital Sveti Duh, HR-10000 Zagreb, Croatia

4 School of Medicine, Josip Juraj Strossmayer University of Osijek, HR-31000 Osijek, Croatia

5 School of Medicine, University of Rijeka, HR-51000 Rijeka, Croatia
6 School of Medicine, University of Split, HR-21000 Split, Croatia
7 Genos Glycoscience Research Laboratory, HR-10000 Zagreb, Croatia

8 Catholic University of Croatia, HR-10000 Zagreb, Croatia
9 University of New Haven, West Haven, CT 06516, USA
10 Department of Biotechnology, University of Rijeka, HR-51000 Rijeka, Croatia
11 Eberly College of Science, The Pennsylvania State University, University Park, PA 16803, USA

* Correspondence: dpolancec@bolnica-srebrnjak.hr (Denis P.); draganprimorac2@gmail.com (Dragan P.); Tel.: +385-99-26-91-216 (Denis P.); +385-98-470-710 (Dragan P.)

Early results of intra-articular micro-fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study

Damir Hudetz¹, Igor Borić², Eduard Rod³, Željko Jeleč³, Barbara Kunovac³, Ozren Polašek⁴, Trpimir Vrdoljak⁵, Mihovil Plečko⁵, Andrea Skelin⁵, Denis Polančec⁶, Lucija Zenić⁶, Dragan Primorac^{6,7,8,9,10,11,12,13}

Leggi articolo

¹University Hospital Sveti Duh, Zagreb, Croatia

²Department of Radiology, St. Catherine Special Hospital, Zabok/Zagreb, Croatia

³Department of Orthopedics, St. Catherine Hospital, Zabok/Zagreb, Croatia

⁴Department of Public Health, School of Medicine, University of Split, Split, Croatia

⁵Specialty Hospital St. Catherine, Croatia

⁶Srebrnjak Children’s Hospital, Zagreb, Croatia

⁷St. Catherine Specialty Hospital, Zabok/ Zagreb, Croatia

⁸Eberly College of Science, The Pennsylvania State University, University Park, PA, USA

⁹University of Split, School of Medicine, Split, Croatia

¹⁰School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

¹¹Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

¹²Faculty of Medicine, University of Rijeka, Rijeka, Croatia

¹³Henry C. Lee College of Criminal Justice and Forensic Sciences, University of New Haven, West Haven, CT, USA

Regenerative Features of Adipose Tissue for Osteoarthritis Treatment in a Rabbit Model: Enzymatic Digestion Versus Mechanical Disruption

Giovanna Desando ¹, Isabella Bartolotti ¹ , Lucia Martini ², Gianluca Giavaresi ²,
Nicolò Nicoli Aldini ², Milena Fini ², Alice Roffi ^3,*, Francesco Perdisa ⁴, Giuseppe Filardo ³, Elizaveta Kon ⁵ and Brunella Grigolo ¹

Leggi articolo

¹Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; giovanna.desando@ior.it (G.D.); isabella.bartolotti@ior.it (I.B.); brunella.grigolo@ior.it (B.G.)

²Laboratory of Preclinical and Surgical Studies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; lucia.martini@ior.it (L.M.); gianluca.giavaresi@ior.it (G.G.); nicolo.nicolialdini@ior.it (N.N.A.); milena.fini@ior.it (M.F.)
³Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; giuseppe.filardo@ior.it
⁴Hip and knee replacement Department, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; francesco.perdisa@ior.it
⁵Humanitas University Department of Biomedical Sciences, Humanitas Clinical and Research Center, 20121 Milan, Italy; Elizaveta.kon@humanitas.it

Antibacterial activity of lipoaspirate: an in vitro study

Chiara Ceresa¹, Letizia Fracchia¹, Carlo Tremolada², Maurizio Rinaldi¹, Michela Bosetti¹

Leggi articolo

¹Department of Pharmaceutical Sciences, Università del Piemonte Orientale “A. Avogadro”, Novara, Italy ²IMAGE Institute, Milano, Italy

Higher Pericyte Content and Secretory Activity of Microfragmented Human Adipose Tissue Compared to Enzymatically Derived Stromal Vascular Fraction

BIANCA VEZZANI,^a ISAAC SHAW,^a HANNA LESME,^a LI YONG,^a NUSRAT KHAN,a CARLO TREMOLADA,^b BRUNO PÉAULT^a,c

Leggi articolo

^aMRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom, ^bImage Institute, Milan, Italy, ^cOrthopaedic Hospital Research Center and Broad Stem Cell Research Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA

Microfragmented human fat tissue is a natural scaffold for drug delivery: Potential application in cancer chemotherapy

Giulio Alessandri ^a,^⁎, Valentina Coccè ^b, Fabio Pastorino ^c, Rita Paroni ^d, Michele Dei Cas ^d, Francesco Restelli ^e, Bianca Pollo ^f, Laura Gatti ^a, Carlo Tremolada ^f,g, Angiola Berenzi ^h, Eugenio Parati ^a, Anna Teresa Brini ^b,i, Gianpietro Bondiolotti ^j, Mirco Ponzoni ^c,1, Augusto Pessina ^b,1

Leggi articolo

^a Cellular Neurobiology Laboratory, Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy ^b CRC StaMeTec, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

^c Laboratory of Experimental Therapy in Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy

^d Clinical biochemistry and mass spectrometry lab, Dept. Health Sciences, University of Milan, Milan, Italy

^e Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

^f Image Institute, University of Milan, Milan, Italy

^g School of Healthcare Science, John Dalton Building, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, UK

^h Section of Pathological Anatomy DMMT, University of Brescia, Brescia, Italy

ⁱ IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

^j Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

A Nonenzymatic and Automated Closed-Cycle Process for the Isolation of Mesenchymal Stromal Cells in Drug Delivery Applications

Valentina Coccè ,¹Anna Brini ,^1,2 Aldo Bruno Giannì ,^1,3Valeria Sordi ,⁴Angiola Berenzi,⁵ Giulio Alessandri,⁶Carlo Tremolada ,⁷ Silvia Versari,⁸ Antonio Bosetto,⁹

Leggi articolo

¹CRC StaMeTec, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
²I.R.C.C.S Galeazzi Orthopedic Institute, Milan, Italy
³Maxillofacial and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via Commenda 10, 20122 Milan, Italy
⁴Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
⁵University Research Center “Integrated Models for Prevention and Protection in Environmental and Occupational Health” (MISTRAL), Brescia, Italy
⁶Cellular Neurobiology Laboratory, Department of Cerebrovascular Diseases, Fondazione IRCCS Neurological Institute C. Besta, Milan, Italy
⁷Image Institute, Milan, Italy
⁸Lipogems International Spa, Milan, Italy 9Hydra srl, Mirandola, Modena, Italy

Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue

Sara Nava,¹ Valeria Sordi ,²Luisa Pascucci,³ Carlo Tremolada ,^4,5Emilio Ciusani,⁶Offer Zeira,⁷Moris Cadei,⁸Gianni Soldati ,⁹Augusto Pessina ,¹⁰Eugenio Parati,¹Mark Slevin ,^5,11,12and Giulio Alessandri ¹

Leggi articolo

¹Cellular Neurobiology Laboratory, Department of Cerebrovascular Diseases, Fondazione IRCCS Neurological Institute C. Besta, Milan, Italy

²Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy
³Department of Veterinary Medicine, University of Perugia, Perugia, Italy
⁴Image Institute, Milan, Italy
⁵School of Healthcare Science, John Dalton Building, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, UK

⁶Laboratory of Clinical Pathology and Neurogenetic Medicine, Fondazione IRCCS Neurological Institute C. Besta, Milan, Italy 7San Michele Veterinary Hospital, Tavezzano con Villavesco, Lodi, Italy

⁸Section of Pathological Anatomy DMMT, University of Brescia, Brescia, Italy
⁹Swiss Stem Cell Foundation, In Pasquée 23, Gentilino, CH-6925 Lugano, Switzerland

¹⁰Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

¹¹Weifang Medical University, Weifang, China
¹²University of Medicine and Pharmacy, Targu Mures, Romania

Functional Outcomes Following Microfragmented Adipose Tissue Versus Bone Marrow Aspirate Concentrate Injections for Symptomatic Knee Osteoarthritis

Kenneth Mautner, ^a,b Robert Bowers, ^a,b Kirk Easley, ^cZachary Fausel,^b Ryan Robinson ^a

Leggi articolo

^aDepartment of Orthopaedics, Emory University, Atlanta, Georgia, USA; ^bDepartment of Physical Medicine and Rehabilitation, Emory University, Atlanta, Georgia, USA; ^cDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health Emory University, Atlanta, Georgia, USA

Functional Outcomes Following Microfragmented Adipose Tissue Versus Bone Marrow Aspirate Concentrate Injections for Symptomatic Knee Osteoarthritis

KENNETH MAUTNER^a,b, ROBERT BOWERS^a,b, KIRK EASLEY^c, ZACHARY FAUSEL^b, RYAN ROBINSON^a

Leggi articolo

Le qualità terapeutiche del tessuto adiposo: Analisi clinica nel trattamento della gonartrosi di grado moderato e severo con Lipogems®

Francesca Zannoni

Leggi articolo

Autologous micro-fragmented adipose tissue for the treatment of diabetic foot minor amputations: a randomized controlled single-center clinical trial

Roberto Lonardi, Nicola Leone*, Stefano Gennai, Giulia Trevisi Borsari, Tea Covic and Roberto Silingardi

Leggi articolo

Treatment of osteoarthritis with autologous and microfragmented adipose tissue

Kristoffer Weisskirchner Barfod¹ & Lars Blønd²

Leggi articolo

Evaluation of fat grafting technique using autologous micro-fragmented adipose tissue (Lipogems®) in female patients suffering from stress urinary incontinence

Janice Santos Cortes* and Danielle Velez

Leggi articolo

Department of Surgery, Urology, The Warren Alpert School of Medicine of Brown University, RI, USA

Rectal advancement flap plus adipose lipofilling (RAFAL) for the treatment of rectourethral fistulas after radical prostatectomy

M. Zuin^1,6 · M. Ruperto² · M. Balduino² · A. Amodeo³ · L. De Zorzi³ · B. Roche⁴ · M. Pavanello⁵ · C. Sernagiotto⁵

Leggi articolo

Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes

OFFER ZEIRA,^a SIMONE SCACCIA,^a LETIZIA PETTINARI,^a ERICA GHEZZI,^a NIMROD ASIAG,^a
LAURA MARTINELLI,^a DANIELE ZAHIRPOUR,^a MARIA P. DUMAS,^a MARTIN KONAR,^a DAVIDE M. LUPI,^a LAURENCE FIETTE,^b LUISA PASCUCCI,^c LEONARDO LEONARDI,^c ALISTAIR CLIFF,^d GIULIO ALESSANDRI,^e AUGUSTO PESSINA,^f DANIELE SPAZIANTE,^g MARINA ARALLA^a

Leggi articolo

Micronized lipoaspirate shows in vitro potential for wound healing

Michela Bosetti¹, Letizia Fracchia¹, Maurizio Rinaldi¹, Chiara Ceresa¹, Alice Marchetti¹, Carlo Tremolada²

Leggi articolo

¹Pharmacological Sciences, University Eastern Piedmont, Novara, Italy; ²IMAGE Institute, Milano, Italy

Autologous Microfragmented Adipose Tissue Reduces the Catabolic and Fibrosis Response in an In Vitro Model of Tendon Cell Inflammation

Marco Viganò,¹ Gaia Lugano,¹ Carlotta Perucca Orfei,¹ Alessandra Menon,^2,3 Enrico Ragni,¹ Alessandra Colombini,¹ Paola De Luca,¹ Pietro Randelli,^2,3 and Laura de Girolamo¹

Leggi articolo

¹Orthopedics Biotechnology Lab, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
²Laboratory of Applied Biomechanics, Department of Biomedical Sciences for Health, Università degli Studi di Milano,

Via Mangiagalli 31, 20133 Milan, Italy
31st Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Piazza Cardinal Ferrari 1,

20122 Milan, Italy

A 24-Month Follow-Up Study of the Effect of Intra-Articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis

Igor Borić ^1,2,3,4, Damir Hudetz ^1,5,6 Eduard Rod ^1,5,6, Željko Jeleč ^1,6,7, Trpimir Vrdoljak ^5,6, Andrea Skelin ^1,8, Ozren Polašek ², Mihovil Plečko ¹, Irena Trbojević-Akmačić⁸, Gordan Lauc ^8,9 and Dragan Primorac ^{1,2,3,4,6,10,11,12,13}

Leggi articolo

¹St. Catherine Specialty Hospital, 49210 Zabok/10000 Zagreb, Croatia; damir.hudetz@svkatarina.hr (D.H.); eduard.rod@svkatarina.hr (E.R.); zeljko.jelec@svkatarina.hr (Ž.J.); andrea.skelin@svkatarina.hr (A.S.); mihovil.plecko@gmail.com (M.P.)
²School of Medicine, University of Split, 21000 Split, Croatia; ozren.polasek@mefst.hr
³Medical School, University of Rijeka, 51000 Rijeka, Croatia
⁴School of Medicine, University of Mostar, 88000 Mostar, Bosnia and Herzegovina
⁵Clinical Hospital “Sveti Duh”, 10000 Zagreb, Croatia; trpimir.vrdoljak@gmail.com
⁶School of Medicine, JJ Strossmayer University of Osijek, 31000 Osijek, Croatia
⁷Department of Nursing, University North, 48 000 Varaždin, Croatia
⁸Genos Glycoscience Research Laboratory, 10000 Zagreb, Croatia; iakmacic@genos.hr (I.T.-A.); glauc@genos.hr (G.L.)
⁹Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
¹⁰Children’s Hospital Srebrnjak, 10000 Zagreb, Croatia
¹¹Eberly College of Science, The Pennsylvania State University, University Park, State College, PA 16802, USA
¹²The Henry C. Lee College of Criminal Justice and Forensic Sciences, University of New Haven, West Haven, CT 06516, USA
¹³School of Medicine, Faculty of Dental Medicine and Health, University “Josip Juraj Strossmayer”, 31000 Osijek, Croatia

Nuove frontiere in colonproctologia: trattare le fistole perianali con cellule mesenchimali da tessuto adiposo, all’Ospedale San Pietro Fatebenefratelli di Roma una delle prime esperienze italiane sulla nuova metodologia

Alessandro Testa

Leggi articolo

Regenerative Features of Adipose Tissue for Osteoarthritis Treatment in a Rabbit Model: Enzymatic Digestion Versus Mechanical Disruption

Giovanna Desando¹, Isabella Bartolotti¹, Lucia Martini², Gianluca Giavaresi², Nicolò Nicoli Aldini², Milena Fini², Alice Roffi³, Francesco Perdisa⁴, Giuseppe Filardo³, Elizaveta Kon⁵ and Brunella Grigolo¹

Leggi articolo

¹Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; giovanna.desando@ior.it (G.D.); isabella.bartolotti@ior.it (I.B.); brunella.grigolo@ior.it (B.G.)
²Laboratory of Preclinical and Surgical Studies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; lucia.martini@ior.it (L.M.); gianluca.giavaresi@ior.it (G.G.); nicolo.nicolialdini@ior.it (N.N.A.); milena.fini@ior.it (M.F.)
³Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; giuseppe.filardo@ior.it
⁴Hip and knee replacement Department, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; francesco.perdisa@ior.it
⁵Humanitas University Department of Biomedical Sciences, Humanitas Clinical and Research Center, 20121 Milan, Italy; Elizaveta.kon@humanitas.it

Effect of microfragmented adipose tissue on osteoarthritic synovial macrophage factors

Leggi articolo

¹SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

²Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

³IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

⁴Department of Biomedical Sciences, Humanitas University, Milan, Italy

⁵Humanitas Clinical and Research Center, Milan, Italy

⁶DIMEC, Alma Mater Studiorum, Università di Bologna, Bologna, Italy

Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue

Sara Nava,¹ Valeria Sordi,² Luisa Pascucci,³ Carlo Tremolada,⁴,⁵ Emilio Ciusani,⁶ Offer Zeira,⁷ Moris Cadei,⁸ Gianni Soldati,⁹ Augusto Pessina,¹⁰ Eugenio Parati,¹ Mark Slevin,⁵,¹¹,¹² and Giulio Alessandri¹

Leggi articolo

¹Cellular Neurobiology Laboratory, Department of Cerebrovascular Diseases, Fondazione IRCCS Neurological Institute C. Besta, Milan, Italy
²Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy
³Department of Veterinary Medicine, University of Perugia, Perugia, Italy
⁴Image Institute, Milan, Italy
⁵School of Healthcare Science, John Dalton Building, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, UK
⁶Laboratory of Clinical Pathology and Neurogenetic Medicine, Fondazione IRCCS Neurological Institute C. Besta, Milan, Italy
⁷San Michele Veterinary Hospital, Tavezzano con Villavesco, Lodi, Italy
⁸Section of Pathological Anatomy DMMT, University of Brescia, Brescia, Italy
⁹Swiss Stem Cell Foundation, In Pasquée 23, Gentilino, CH-6925 Lugano, Switzerland
¹⁰Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
¹¹Weifang Medical University, Weifang, China
¹²University of Medicine and Pharmacy, Targu Mures, Romania

Microfragmented adipose injections in the treatment of knee osteoarthritis

Gerard A. Malanga^a, Sean Bemanian^b

Leggi articolo

^a New Jersey Regenerative Institute Clinical Professor Department of PM&R Rutgers School of Medicine-NJ Medical School Cedar Knolls, NJ, 07927, USA
^b Sports and Regenerative Medicine Fellow New Jersey Regenerative Institute Cedar Knolls, NJ, 07927, USA

Utilizzo di staminali da tessuto adiposo nelle lesioni cutanee croniche: esperienza clinica Use of adipose tissue stem cells in chronic skin lesions: clinical experience

Fabrizio Moffa, Alberico Balbiano da Colcavagno, Elia Ricci

Leggi articolo

U.O.A. Ferite Difficili Casa di Cura e Riposo San Luca, Pecetto Torinese (TO), Italia

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Riccardo D’Ambrosi¹,², Cristian Indino¹, Camilla Maccario¹, Luigi Manzi¹, Federico Giuseppe Usuelli¹

Leggi articolo

1IRCCS Istituto Ortopedico Galeazzi – C.A.S.C.O. Piede e Caviglia
2Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano

Mesenchymal Stem Cells injection in hip osteoarthritis: preliminary results

Carlo Dall’Oca, Stefano Breda, Nicholas Elena, Roberto Valentini, Elena Manuela Samaila, Bruno Magnan

Leggi articolo

Department of Orthopaedic and Trauma Surgery, University Hospital, Verona, Italy

Autologous adipose tissue graft in the vulva in severe vulvar lichen sclerosus atrophicus: clinical case

Davide De Vita¹, Carmen Sciorio², Serena Spartano³

Leggi articolo

1 UOC Ostetricia-Ginecologia PO [Obstetrics-Gynaecology Department] S. Santa Maria della Speranza, Battipaglia, SA
2 UOC Ostetricia-Ginecologia Ospedale S. Maria delle Grazie, Pozzuoli, NA
3 Haematology Department, Università Cattolica del Sacro Cuore [Catholic University of the Sacred Heart], Rome

Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3 year follow-up

A. Russo1,2*, D. Screpis1, S. L. Di Donato1, S. Bonetti1, G. Piovan1 and C. Zorzi1

Leggi articolo

Preliminary results of autologous adipose-derived stem cells in early knee osteoarthritis: identification of a subpopulation with greater response

Alfredo Schiavone Panni¹ & Michele Vasso¹ & Adriano Braile¹ & Giuseppe Toro¹ & Annalisa De Cicco¹ & Davide Viggiano² & Federica Lepore¹

Leggi articolo

A nonenzymatic and automated closed-cycle process for the isolation of mesenchymal stromal cells in drug delivery applications

Valentina Coccè, 1 Anna Brini, 1, 2 Aldo Bruno Giannì, 1, 3 Valeria Sordi, 4 Angiola Berenzi, 5 Giulio Alessandri, 6 Carlo Tremolada, 7 Silvia Versari, 8 Antonio Bosetto, 9 and Augusto Pessina

Leggi articolo

CRC StaMeTec, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
2
I.R.C.C.S Galeazzi Orthopedic Institute, Milan, Italy
3
Maxillofacial and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via Commenda 10, 20122 Milan,
Italy
4
Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy 5
University Research Center “Integrated Models for Prevention and Protection in Environmental and Occupational Health”
(MISTRAL), Brescia, Italy
6
Cellular Neurobiology Laboratory, Department of Cerebrovascular Diseases, Fondazione IRCCS Neurological Institute C. Besta,
Milan, Italy
7
Image Institute, Milan, Italy
8
Lipogems International Spa, Milan, Italy
9
Hydra srl, Mirandola, Modena, Italy

Mesenchymal stem cells and regenerative medicine: how Lipogems make them easy, safe and more effective to use

Carlo Tremolada Image institute, Italy

Leggi articolo

Correspondence: Carlo Tremolada, Image institute, Italy,
Email carlo.tremolada@gmail.com

Safety and Efficacy of Percutaneous Injection of Lipogems Micro-Fractured Adipose Tissue for Osteoarthritic Knees

Jay Panchal, MD Gerard Malanga, MD Mitchell Sheinkop, MD

Leggi articolo

Micro-Fractured Adipose Tissue for Osteoarthritic Knees. Am J Orthop.

Micro-fragmented adipose tissue injection associated with arthroscopic procedures in patients with symptomatic knee osteoarthritis

G. Cattaneo^1*, A. De Caro¹, F. Napoli¹, D. Chiapale², P. Trada², A. Camera¹

Leggi articolo

¹Spotorno Foundation c/o San Michele Clinics, Viale Pontelungo, 79, 17031 Albenga, SV, Italy
²Orthopaedic Department, San Paolo Hospital, Savona, SV, Italy
^*Correspondence: gabrielecattaneo@hotmail.com

Micro‑fragmented adipose tissue injection for the treatment of complex anal fistula: a pilot study accessing safety and feasibility

G. Naldini¹, A. Sturiale¹, B. Fabiani¹, I. Giani¹, C. Menconi¹

Leggi articolo

¹Proctological and Perineal Surgery Unit, Cisanello University Hospital, Via Paradisa 2, Pisa, Italy

Mini Review: Mesenchymal Stem Cells and Regenerative Medicine: How Lipogems Technology Make Them Easy, Safe and More Effective to Use

Carlo Tremolada^*

Leggi articolo

^*Corresponding author: Carlo Tremolada, Image institute, Italy, Email: carlo.tremolada@gmail.com

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

Giovanni Marfia^1*,#, Stefania Elena Navone^1,#, Clara Di Vito², Nicola Ughi³, Silvia Tabano⁴, Monica Miozzo⁴, Carlo Tremolada⁵, Gianni Bolla⁶, Chiara Crotti³, Francesca Ingegnoli³, Paolo Rampini¹, Laura Riboni², Roberta Gualtierotti³, Rolando Campanella¹ (2015)

Leggi articolo

¹Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico; University of Milan; Neurosurgery Unit; Laboratory of Experimental Neurosurgery and Cell Therapy; Milan, Italy
²University of Milan; Department of Medical Biotechnology and Translational Medicine; LITA-Segrate; Milan, Italy
³Division of Rheumatology; Istituto Gaetano Pini; Milan Italy; Department of Clinical Science & Community Health; University of Milan; Milan, Italy
⁴Fondazione IRCCS C a Granda Ospedale Maggiore Policlinico; University of Milan; Division of Pathology; Milan, Italy
⁵Istituto Image; Milan, Italy
⁶Fondazione IRCCS C a Granda Ospedale Maggiore Policlinico; University of Milan; Milan, Italy

^*Correspondence to: Giovanni Marfia; Email: giovanni.marfia@unimi.it
^#Co-first authors

Menopause: new frontiers in the treatment of urogenital atrophy

G.A. CASAROTTI1, P. CHIODERA2, C. TREMOLADA1

Leggi articolo

1Image Institute, Milan, Italy
2Department of Pathology, Synlab, Castenedolo (BS), Italy

The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling

Giovanni Marfia^1,*, Stefania Elena Navone^1,*, Loubna Abdel Hadi^2,*, Moira Paroni³, Valeria Berno³, Matteo Beretta¹, Roberta Gualtierotti⁴, Francesca Ingegnoli⁴, Vincenzo Levi², Monica Miozzo⁵, Jens Geginat³, Lorenzo Fassina⁶, Paolo Rampini¹, Carlo Tremolada⁷, Laura Riboni^2,† and Rolando Campanella^1,† (2016)

Leggi articolo

¹Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
²Department of Medical Biotechnology and Translational Medicine, LITA-Segrate, University of Milan, Milan, Italy.
³Istituto Nazionale di Genetica Molecolare ‘‘Romeo ed Enrica Invernizzi,’’ Milan, Italy.
⁴Division of Rheumatology, Istituto Gaetano Pini, Milano, Italy.
⁵Division of Pathology, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
⁶Department of Health Sciences and Industrial and Information Engineering, University of Pavia, Pavia, Italy.
⁷Istituto Image, Milan, Italy.
^*These authors contributed equally to this work and are considered co-first author

Lipogems Product Treatment Increases the Proliferation Rate of Human Tendon Stem Cells without Affecting Their Stemness and Differentiation Capability

Pietro Randelli^1,2, Alessandra Menon¹, Vincenza Ragone¹, Pasquale Creo¹, Sonia Bergante¹, Filippo Randelli¹, Laura De Girolamo³, Umberto Alfieri Montrasio³, Giuseppe Banfi^3,4, Paolo Cabitza¹, Guido Tettamanti¹ and Luigi Anastasia1² (2015)

Leggi articolo

¹IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy
²Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy
³IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy
⁴Universita` Vita-Salute San Ra aele, 20132 Milan, Italy

Transnasal endoscopic microfractured fat injection in glottic insufficiency

A. M. Saibene, C. Pipolo, R. Lorusso, S. M. Portaleone and G. Felisati (2015)

Leggi articolo

Otolaryngology Department San Paolo Hospital, Department of Health Sciences, University of Milan, Milan, Italy

Lipoaspirate as Autologous Injectable Active Scaffold for One-Step Repair of Cartilage Defects

Michela Bosetti^*, Alessia Borrone^†, Antonia Follenzi^†, Fanuel Messaggio^‡, Carlo Tremolada^§, and Mario Cannas^† (2015)

Leggi articolo

^*Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Novara, Italy.
^†Dipartimento di Scienze della Salute, Università del Piemonte Orientale, Novara, Italy.
^‡Diabetes Research Institute, University of Miami, Miami, FL, USA.
^§IMAGE Institute, Milan, Italy.

The Effect of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis

Damir Hudetz^1,2,3,*, Igor Borić^1,2,4,5, Eduard Rod¹, Željko Jeleč¹, Andrej Radić¹, Trpimir Vrdoljak^1,2, Andrea Skelin^1,6, Gordan Lauc^6,7, Irena Trbojević-Akmačić⁶, Mihovil Plečko⁸, Ozren Polašek^4,7, and Dragan Primorac^{1,3,4,9,10,11,12,*} (2017)

Leggi articolo

¹St. Catherine Specialty Hospital, 49210 Zabok/ 10000 Zagreb, Croatia; igor.boric@svkatarina.hr (I.B.); eduard.rod@svkatarina.hr (E.R.); zeljko.jelec@svkatarina.hr (Z.J.); andrej.radic@svkatarina.hr (A.R.); trpimir.vrdoljak@svkatarina.hr (T.V.); andrea.skelin@svkatarina.hr (A.S.)
²Clinical Hospital “Sveti Duh”, 10000 Zagreb, Croatia
³School of medicine, JJ Strossmayer University of Osijek, 31000 Osijek, Croatia
⁴School of Medicine, University of Split, 21000 Split, Croatia; ozren.polasek@mefst.hr
⁵University of Rijeka, Medical School, 51000 Rijeka, Croatia
⁶Genos Glycoscience Research Laboratory, 10000 Zagreb, Croatia; glauc@genos.hr (G.L.); iakmacic@genos.hr (I.T.-A.)
⁷Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
⁸School of Medicine, University of Zagreb, 10000 Zagreb, Croatia; mihovil.plecko@gmail.com
⁹Gen-info, 10000 Zagreb, Croatia
¹⁰Children’s Hospital Srebrnjak, 10000 Zagreb, Croatia
¹¹Eberly College of Science, The Pennsylvania State University, University Park, State College, 16802 PA, USA
¹²The Henry C. Lee College of Criminal Justice and Forensic Sciences, University of New Haven, West Haven, 06516 CT, USA
^*Correspondence: ortohud@gmail.com (D.H.); draganprimorac2@gmail.com (D.P.); Tel.: +385-98-235-623 (D.H.); +385-98-470-710 (D.P.)

Angiogenic and anti-inflammatory properties of micro-fragmented fat tissue and its derived mesenchymal stromal cells

Valentina Ceserani^1†, Anna Ferri^1*†, Angiola Berenzi², Anna Benetti², Emilio Ciusani³, Luisa Pascucci⁴, Cinzia Bazzucchi⁴, Valentina Coccè⁵, Arianna Bonomi⁵, Augusto Pessina⁵, Erica Ghezzi⁶, Offer Zeira⁶, Piero Ceccarelli⁴, Silvia Versari⁷, Carlo Tremolada⁷ and Giulio Alessandri¹ (2016)

Leggi articolo

¹Cellular Neurobiology Laboratory, Department of Cerebrovascular Diseases, IRCCS Neurological Institute C. Besta, Via Celoria 11, 20131 Milan, Italy
²Department of Clinical and Experimental Sciences, Institute of Pathological Anatomy, University of Brescia, Brescia, Italy
³Laboratory of Clinical Pathology and Neurogenetic Medicine, Fondazione IRCCS Neurological Institute C. Besta, Milan, Italy.
⁴Department of Veterinary Medicine, University of Perugia, Perugia, Italy
⁵Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
⁶San Michele Veterinary Hospital, Tavezzano con Villavesco, Lodi, Italy
⁷Image Institute, Milan, Italy
^†Equal contributors
^*Correspondence: anna.ferri@istituto-besta.it

Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis

A. Russo¹, V. Condello¹, V. Madonna¹, M. Guerriero², C. Zorz¹ (2017)

Leggi articolo

¹Orthopaedic Department, Sacro Cuore – Don Calabria Hospital, Via Don A. Sempreboni, 5, 37024 Negrar, VR, Italy
²Computer Science Department, University of Verona, Verona, VR, Italy

Non-Responding Knee Pain with Osteoarthritis, Meniscus and Ligament Tears Treated with Ultrasound Guided Autologous, Micro-Fragmented and Minimally Manipulated Adipose Tissue

Richard David Striano¹, Valeria Battista², Norma Bilboo¹ (2017)

Leggi articolo

¹Optimum Joint, New York, USA
²Istituto Image, Milano, Italy

Microfractured and Purified Adipose Tissue (LipogemsTM system) Injections forTreatment of Atrophic Vaginitis

Jennifer Fantasia¹, Halland Chen², Janice A. Santos Cortes¹ (2016)

Leggi articolo

¹Department of Urology, Brown University, USA
²Department of Regenerative Medicine, Brown University, USA

Low back pain treated with disc decompression and autologous micro-fragmented adipose tissue: a case report

P. Grossi¹, S. Giarratana², S. Cernei³, S. Grossi⁴, F.M. Doniselli⁵

Leggi articolo

CellR4 2016; 4 (1): e1772
¹O.U. Regional Anesthesia and Pain Treatment, IRCCS Policlinico San Donato, Milan, Italy
²Faculty of Medicine, University of Milan, Milan, Italy
³School of Specialization in Anesthesiology, University Amadeo Avogadro, Novara, Italy
⁴School of Specialization in Orthopedics and Traumatology, University of Pisa, Pisa, Italy
⁵School of Specialization in Radiology, University of Milan, Milan, Italy

Injection of autologous micro-fragmented adipose tissue for the treatment of post-traumatic degenerative lesion of knee cartilage: a case report

M. Franceschini, C. Castellaneta, G. Mineo

Leggi articolo

CellR4 2016; 4 (1): e1768
Orthopaedic and Trauma Department, Istituto Ortopedico “G. Pini”, University of Milan, Milan, Italy

Microfractured Lipoaspirate May Help Oral Bone and Soft Tissue Regeneration: a Case Report

R. Benzi¹, G. Marfia³, M. Bosetti⁴, G. Beltrami², A.S. Magri², S. Versari², C. Tremolada² (2015)

Leggi articolo

¹Benzi Dental Clinic, Vigevano (PV), Italy
²Image Institute, Milan, Italy
³Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS, CA’ Granda Ospedale Policlinico, Milan, Italy
⁴Human Anatomy, Scienze del Farmaco Department, UPO, Novara, Italy

Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development

C. Tremolada*, V. Colombo*, C. Ventura** (2016)

Leggi articolo

*Image Institute, Milan, Italy
**Stem Wave Institute for Tissue Healing (SWITH)—Ettore Sansavini Health Science Foundation, Lugo, Ravenna, Italy

The Use of Physical Energy for Tissue Healing

C. Ventura*, F. Bianchi, C. Cavallini, E. Olivi, R. Tassinari

Leggi articolo

European Heart Journal Supplements (2015)17: A69-A73
*Stem Wave Institute for Tissue Healing (SWITH), E. Sansavini Health Science Foundation, Ravenna, Italy

Non-Responsive Knee Pain with Osteoarthritis and Concurrent Meniscal Disease Treated With Autologous Micro-Fragmented Adipose Tissue Under Continuous Ultrasound Guidance

R.D. Striano, H. Chen, N. Bilbool, K. Azatullah, J. Hilado, K. Horan

Leggi articolo

CellR4 2015; 3 (5): e1690
Regenerative Medicine, Optimum Joint, New York, USA

Recovery of Function in Anal Incontinence after Micro-Fragmented Fat Graft (Lipogems®) Injection: Two Years Follow Up of the First 5 Cases.

A. Giori*, C. Tremolada, R. Vailati, S.E. Navone, G. Marfia, A.I. Caplan

Leggi articolo

CellR4 (2015), 3 (2): e1544
*Department of General Surgery, San Paolo University Hospital, Milan, Italy

Adipose Mesenchymal Stem Cells and “Regenerative Adipose Tissue Graft” (Lipogems®TM) for Musculoskeletal Regeneration

C. Tremolada*, G. Beltrami, A. Magri, F. Bianchi, C. Ventura, C. Di Vito, R. Campanella, S.E. Navone, G. Marfia And A.I. Caplan

Leggi articolo

European Journal of Musculoskeletal Diseases (2014), Vol. 3, no. 2
*Image Institute, Milan, Italy

Human Stem Cell Exposure to Developmental Stage Zebrafish Extracts: a Novel Strategy for Tuning Stemness and Senescence Patterning

S. Canaider*, M. Maioli, F. Facchin, E. Bianconi, S. Santaniello, G. Pigliaru, L. Ljungberg, F. Burigana, F. Bianchi, E. Olivi, C. Tremolada, P. M. Biava and C. Ventura

Leggi articolo

CellR4 (2014) 2(5), e1226
*Department of Specialistic, Diagnostic, and Experimental Medicine, University of Bologna, Italy

Fair or Foul: Time for Standard Protocols for Potential Application of Adipose-Derived Stem Cells

Y. Zhao, C. Betzler, F. Popp and C. Bruns*

Leggi articolo

J Stem Cell Res Ther (2014), 4(220):2
* Department of General, Visceral und Vascular Surgery, Otto-von-Guericke University, Germany

Radioelectric Asymmetric Conveyed Fields and Human Adipose-Derived Stem Cells Obtained With a Nonenzymatic Method and Device: A Novel Approach to Multipotency

M. Maioli,*†‡ S. Rinaldi, S. Santaniello, A. Castagna, G. Pigliaru, A. Delitala, F. Bianchi, C. Tremolada, V. Fontani, and C. Ventura

Leggi articolo

Cell transplantation (2014), 23(12): 1489-1500
*Department of Biomedical Sciences, University of Sassari, Sassari, Italy
†Laboratory of Molecular Biology and Stem Cell Engineering – National Institute of Biostructures and Biosystems, Bologna, Italy
‡Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence, Italy

Differences in exosome content of human adipose tissue processed by non-enzymatic and enzymatic methods

M. García-Contreras*, F. Messaggio, O. Jimenez, A. Mendez

Leggi articolo

CellR4 (2014), 3 (1): e1423
* Diabetes Research Ins”tute,University ofMiami,Miller School ofMedicine,Miami, FL,USA

Case report Intersphincteric anal lipofilling with micro-fragmented fat tissue for the treatment of faecal incontinence: preliminary results of three patients

G. Cestaro*, M. De Rosa, S. Massa, B. Amato, M. Gentile

Leggi articolo

Videosurgery and Other Miniinvasive Techniques (2014), DOI: 10.5114/wiitm.2014.47435
*Department of General and Mininvasive Surgery University of Naples Federico II, Napoli, Italy

Lipogems®, a New Modality of Fat Tissue Handling to Enhance Tissue Repair in Chronic Hind Limb Ischemia

F. Bianchi*, E. Olivi, M. Baldassarre, F.A. Giannone, M. Laggetta, S. Valente, C. Cavallini, R. Tassinari, S. Canaider, G. Pasquinelli, C. Tremolada, C. Ventura

Leggi articolo

CellR4 (2014) 2 (6): e1289
*Stem Wave Institute for Tissue Healing (SWITH), E. Sansavini Health Science Foundation, Ravenna, Italy

Characteristics and Properties of Mesenchymal Stem Cells Derived from Micro-fragmented Adipose Tissue.

Carelli S.*, Messaggio F., Canazza A., Hebda D., Caremoli F., Latorre E., Grimoldi M.G., Colli M., Bulfamante G., Tremolada C.

Leggi articolo

Cell Transplant. 2014 April 29. [Accepted for pubblication].
*Laboratorio di Farmacologia, Dipartimento di Scienze della Salute, Università degli Studi di Milano.

Micro Fractured and Purified Adipose Tissue Graft (Lipogems®) Can Improve the Orthognathic Surgery Outcomes Both Aesthetically and in Postoperative Healing

Raffaini M., Tremolada C.

Leggi articolo

CellR4 2014; 2 (4): e1118. 2014 July 28

Ricerca di nuove strategie differenziative: analisi degli effetti di stimoli fisici e molecolari su cellule mesenchimali umane isolate da tessuto adiposo

E. Bianconi (2014)

Leggi articolo

Dottorato di Ricerca in Scienze Farmacologiche, Tossicologiche, dello Sviluppo e Movimento Umano.
*Alma Mater Studiorum – University of Bologna, Italy

Mesenchymal Stem Cells from human adipose tissue: Characterization and Immunomodulatory Properties of Tissue and Cellular Products

Messaggio, F. (2013)

Leggi articolo

Dottorato di Ricerca Fisiopatologia, Farmacologia, Clinica e Terapia delle Malattie Metaboliche. University of Milan, Italy.

Adipose-derived stem cells and tissue revascularization: enhancing islet survival and performance for diabetes care

Olivi, E. (2013)

Leggi articolo

Dottorato Di Ricerca In Scienze Chirurgiche. Alma Mater Studiorum – University of Bologna, Italy

A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte- like elements by mild mechanical forces from human lipoaspirate

F. Bianchi*, M. Maioli, E. Leonardi, E. Olivi, G. Pasquinelli, S. Valente, A.J. Mendez, C. Ricordi, M. Raffaini, C. Tremolada and C. Ventura

Leggi articolo

Cell transplantation (2013), 22(11): 2063-2077
*Laboratory of Molecular Biology and Stem Cell Engineering-National Institute of Biostructures and Biosystems, Bologna, Italy

Preparation and method for producing a preparation comprising mesenchymal stem cells

Tremolada C (2013) – US Patent App. 14/382,298

Leggi articolo

Radio electric asymmetric conveyed fields and human adipose-derived cells obtained with a non-enzymatic method and device: a novel approach to multipotency

Maioli M.*, Rinaldi S., Santaniello S., Castagna A., Pigliaru G., Delitala A., Bianchi F., Tremolada C., Fontani V., Ventura C.

Leggi articolo

Cell Transplant. 2013 Aug 30. doi: 10.3727/096368913X672037. [Epub ahead of print]
*Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Bologna, Italy

Adipocyte transplantation and stem cells: plastic surgery meets regenerative medicine.

Tremolada C.*, Palmieri G., Ricordi C.

Leggi articolo

Cell Transplant. 2010;19(10):1217-23. doi: 10.3727/096368910X507187. Epub 2010 May 4.
*Istituto Image and San Paolo Hospital, Milan, Italy

Pubblicazioni Lipogems®

Filtri