Micro fractured Adipose Tissue Graft (Lipogems), Regenerative Surgery and Potential Outcomes for Infectious and Cancer Diseases

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In the past few years, interest in adipose tissue as an ideal source of mesenchymal stem cells (MSCs) has increased since they are able to secrete many bioactive molecules and exosomes. MSCs are being used increasingly for many clinical applications, such as orthopedic, plastic, and reconstructive surgery. An innovative technique (Lipogems®) has been developed to obtain micro fragmented adipose tissue (MFAT) with an intact stromal vascular niche and MSCs with a high regenerative capacity. The Lipogems technology, is an easy-to-use system designed to harvest, process, and inject refined fat tissue and is characterized by optimal handling ability and a great regenerative potential based on adipose-derived MSCs. As a further step, bioactive molecules and exosomes produced either by the MSCs extracted and from Lipogems/MFAT itself will be studied by Exogems Inc., a new venture that will leverage the potential of this secretome to treat infections and cancer.


Carlo Tremolada, Pierre Rocheteau, Carmelo Bisognano, Ofer Zeira, Giulio Alessandri.


Journal of Stem Cell Research